Method of treating ciliary dyskinesia with dinucleoside polyphosphate compounds or UTP analogues

US6673779B2 · kind B2 · utility

Assignees

• Inspire Pharmaceuticals, Inc. · US
• The University of North Carolina at Chapel Hill · US

Inventors

• Karla M. Jacobus · Cary, US
• Benjamin R. Yerxa · Raleigh, US
• William Pendergast · Durham, US
• Richard C. Boucher, Jr. · Chapel Hill, US
• Janet L. Rideout · Raleigh, US
• David Drutz · Chapel Hill, US
• Michael James · Raleigh, US
• Monroe Jackson Stutts · Chapel Hill, US
• Cara Geary · Seattle, US
• Eduardo R. Lazarowski · Durham, US

Key dates

• Filing date: Jun 5, 2002
• Grant date: Jan 6, 2004
• Expiry date: Jun 5, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H21/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to a method of stimulating ciliary beat frequency to promote mucociliary or cough clearance of retained mucus secretions from the lungs, sinuses, upper airways, ears, eyes, genito-urinary tract, spermatozoa, ovaries, fallopian tubes, neutrophils, and macrophages of a patient. The method comprises administering uridine triphosphates, adenosine triphosphates, cytidine triphosphates, or dinucleoside tetraphosphates and the derivatives thereof to an affected body of a patient, to treat dysfunction of the mucociliary clearance system as a result of impaired ciliary movement in the patient.