Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders

US6673816B1 · kind B1 · utility

Assignees

• Angelika Esswein · DE
• Wolfgang Schafer · DE
• Konrad Honold · DE

Inventors

• Angelika Esswein · Büttelborn, DE
• Wolfgang Schaefer · Sankt Augustin, DE
• Christos Tsaklakidis · Weinheim, DE
• Konrad Honold · Penzberg, DE
• Klaus Kaluza · Bad Heilbrunn, DE

Key dates

• Filing date: Jun 21, 2001
• Grant date: Jan 6, 2004
• Expiry date: Jun 21, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D493/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of general formula (I), in which m is 0-8, q is a 0-8, a is 0-4, A signifies a single or double bond, R1, R2 signify hydrogen or lower alkyl and, when m signifies 2-8, R1 and R2 in the group CR1═CR2 can have various significances within the following sequence, R3 signifies hydrogen or lower alkyl, X signifies hydrogen or —(CH2)b—COR4 with b=0-4, Y signifies hydrogen, —COR4, phenyl or indolyl residue R4 signifies hydroxyl, lower alkoxy or the NR1R2 residue, W signifies an optionally mono- or polysubstituted saturated or unsaturated mono-, bi- or tricycle which can contain hetero atoms, as well physiologically compatible salts, esters, optically active forms, racemates, tautomers, and derivatives which can be metabolized in vivo to compounds of general formula (I).