Analogs of 2-Phthalimidinoglutaric acid
US6673828B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | May 11, 1999 |
| Grant date | Jan 6, 2004 |
| Priority date | — |
| Expiry date | May 11, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/46
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides new and useful analogs of 2-phthalimidinoglutaric acid. These analogs include DL-2-methyl-2-phthalimidinoglutaric acid and hydroxylated analogs of 2-phthalimidinoglutaric. The invention also provides processes for making these analogs. The invention also provides the two individual enantiomers of DL-2-methyl-2-phthalimidinoglutaric acid, (R)-(+)-2-methyl-2-phthalimidinoglutaric acid and (S)-(−)-2-methyl-2-phthalimidinoglutaric acid, and processes for separating these individual enantiomers from the racemate. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases, including cancer and macular degeneration, by administering one or more of these compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.