Methods and compositions for the manufacture of C-3′ and C-4′ anthracycline antibiotics
US6673907B2 · kind B2 · utility
6Cited by
3References
48Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 19, 2001 |
| Grant date | Jan 6, 2004 |
| Priority date | — |
| Expiry date | Sep 19, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/704
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses new and novel substituted anthracyclines with modified alkyl-aromatic ring substitutions on the C-3′ of the sugar moiety or modified or unmodified alkyl-aromatic ring substitutions at the C-4′ of the sugar moiety. It also discloses novel methods for the preparation of sugar substrates and methods for the preparation of anthracycline antibiotics. These anthracycline analogs show high cytotoxicity in vitro against several tumor cell lines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.