Method of producing thiobarbituric acid derivatives
US6673925B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 20, 2001 |
| Grant date | Jan 6, 2004 |
| Priority date | — |
| Expiry date | Aug 26, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/60
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Method of producing thiobarbituric acid derivatives of formula I whereinR1 is SH, S−M+ or CH3S—, and M+ is an alkali metal ion, by hydrogenolysis of a compound of formula II wherein R2 is chlorine or CH3O—, witha) a hydrogenolysis agent in the presence of an inert solvent and by a direct reaction of the hydrogenolysis product with an alkali metal methylate in methanol, orb) with a hydrogenolysis agent in the presence of an inert solvent and in the presence of a methylation reagent, and subsequently with an alkali metal methylate in methanol, as well as the use of these compound of formula I in the production of 7-[(4,6-dimethoxy-pyrimidin-2-yl)thio]-3-methylphthalide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.