Compositions and methods relating to cyclic compounds that undergo nucleotide base pair-specific interactions with double-stranded nucleic acids
US6673940B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 6, 2000 |
| Grant date | Jan 6, 2004 |
| Priority date | — |
| Expiry date | Jan 6, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The design, synthesis, and use of cyclic compounds, including cyclic polyamides, is described. Such compounds comprise at least two polymer portions, one of which comprises at least three molecular units, and the other comprises at least four molecular units. At least one molecular unit of such a compound is a hydrogen bond donor or acceptor. The polymer portions are covalently linked to form a cycle. These compounds are capable of targeting specific nucleotide sequences in double-stranded nucleic acids, particularly double-stranded DNA. Accordingly, such compounds can be used to modulate, e.g., increase or decrease, the expression of one or more genes in vitro or in vivo.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.