Resolution of DL-racemic mixtures

US6673942B1 · kind B1 · utility

Assignees

• Degussa AG · DE
• YEDA RESEARCH AND DEVELOPMENT CO. LTD. · IL

Inventors

• Matthias Kottenhahn · Alzenau, DE
• Guenter Knaup · Bruchköbel, DE
• Karlheinz Drauz · Alzenau, DE
• Meir Lahav · Rehovot, IL
• David Zbaida · Givatayim, IL

Key dates

• Filing date: Jul 23, 2002
• Grant date: Jan 6, 2004
• Expiry date: Jul 23, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for the resolution of DL-racemic mixtures of compounds which crystalize in the form of a conglumerate. Both, the D and L-enantiomers are obtained according to the invention in a industrially feasable process by adding chiral enantioselective polymers to the supersaturated solution of the racemat to inhibit crystalization of one enantiomer. Next a DL-racemic mixture of said compound is suspended in about twice the amount of the crystallized enantiomer. Consequently, the opposite enantiomer could be recovered by said suspension by physical separation.