Patent · US Expired

Structure-based identification of candidate compounds using three dimensional structures and models of Fc receptors

US6675105B2 · kind B2 · utility

16Cited by

0References

51Claims

0Family size

Assignee

Ilexus Pty Limited · AU

Inventors

P. Mark Hogarth · Williamstown, AU
Maree Powell · Cockatoo, AU
Ian McKenzie · McLaren Vale, AU
Kelly F. Maxwell · Melbourne, AU
Thomas P. J. Garrett · Brunswick, AU
Vidana Epa · Melbourne, AU

Key dates

Filing date	Feb 5, 1999
Grant date	Jan 6, 2004
Priority date	—
Expiry date	Feb 5, 2019

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A90/10
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed are crystals, crystal structure Fc&ggr;RIIa protein, three dimensional coordinates of Fc&ggr;RIIa protein, and structures and models derived from the Fc&ggr;RIIa structure. Also disclosed are crystals of Fc&egr;RI protein and three dimensional coordinates of Fc&egr;RI protein monomers and dimers derived from the Fc&ggr;RIIa structure. Also disclosed are three dimensional coordinates of Fc&ggr;RIIIb proteins and models of Fc&ggr;RIIIb derived from the Fc&ggr;RIIa structure. The present invention also includes methods to produce such crystals, crystal structures and models. Uses of such crystals, crystal structures and models are also disclosed, including structure based drug design and therapeutic compositions.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.