Bovine lactation associated immunotropic protein (CD14), encoding gene and application in B cell activation
US6676985B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | May 18, 1999 |
| Grant date | Jan 13, 2004 |
| Priority date | — |
| Expiry date | May 18, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S426/801
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A protein purified from bovine colostral whey and isolated nucleotide sequences encoding the protein is identified. The isolated bovine protein is termed Bovine Lactation Associated Immunotropic (Bo-LAIT) protein. The human homologue of Bo-LAIT protein, Hu-LAIT protein, is also described. A method of activating B cells, and particularly of activating B cells in a mammal, such as a human, in need of such activation by administering LAIT protein is described. LAIT protein can be incorporated into infant formula. LAIT protein can be administered to an infant, as by feeding to the infant such formula. LAIT protein can be incorporated as part of a vaccination, LAIT protein can be administered to a patient having a T cell immune deficiency, for example, a particular T cell dysfunction in which gp39 (CD40L) is under expressed on or totally absent from the cell surface of patient T cells. Preparation of medicaments including LAIT protein for activating B cells in a mammal in need of such activation is described. Natural or recombinant LAIT protein can be used.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.