Aerogels and other coatings as collection media and matrix supports for MALDI-MS applications
US6677161B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 10, 2001 |
| Grant date | Jan 13, 2004 |
| Priority date | — |
| Expiry date | Apr 27, 2022 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/255
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Techniques to modify and apply aerogel coatings are described, including the application of spray-coated aerogels. The approach eliminates several of the wet chemical techniques previously needed for processes such as MALDI processing, and simplifies the automation of processes such as continuous monitoring in a sensor based format. With respect to MALDI processing, the preferred embodiment uses an acid-doped silica aerogel coated tape as the collection media as well as the matrix support. Although aerogels are disclosed as a preferred matrix material, other materials may alternatively be used, including linoleic acids, oleic acids, PEG (polyelthylene glycol), preferably in tape format.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.