Beta-fluoroethyl thiourea compounds and use
US6677350B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Sep 21, 2000 |
| Grant date | Jan 13, 2004 |
| Priority date | — |
| Expiry date | Sep 21, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to compounds, compositions and methods for the prevention or treatment of mycobacterium infections. The compounds are naturally occurring and synthetic biflavonoids, flavonoids, chalcones and chalcone like compounds. The compounds were screened for anti-mycobacterium activity. Of the compounds showing anti-mycobacterium activity, eight were identified as particularly potent, exhibiting greater than 90% inhibition of the growth of Mtb at a concentration of 12.5 &mgr;g/mL. The actual minimum inhibitory concentrations (MIC), defined as the lowest concentration inhibiting 99% of the inoculum, for the preferred compounds ranged from 6.8 to 48.3 &mgr;M.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.