Mammaglobin, a secreted mammary-specific breast cancer protein
US6677428B1 · kind B1 · utility
10Cited by
7References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 30, 2000 |
| Grant date | Jan 13, 2004 |
| Priority date | — |
| Expiry date | May 30, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/112
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A purified and isolated DNA sequence and the encoded mammary-specific secreted protein, mammaglobin, are disclosed. Also disclosed are methods for detecting breast cancer based upon the overexpression and secretion of mammaglobin by breast cancer cells. The methods detect and/or quantitate the presence of mammaglobin or the mRNA encoding mammaglobin. Immunotherapy-based methods for treating a breast cancer patient with a mammaglobin-expressing tumor are also disclosed. The methods involve using mammaglobin antigens to induce a humoral and/or cell-mediated immune response against the tumor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.