Echinocandin derivatives, preparation method and application as anti-fungal agents

US6677429B1 · kind B1 · utility

Assignee

• AVENTIS PHARMA S.A. · FR

Inventors

• Olivier Courtin · Neuilly-sur-Seine, FR
• Patrick Fauveau · Livry-Gargan, FR
• Astrid Markus · Liederbach, DE
• Dominique Melon Manguer · Montreuil, FR
• Jean-Marc Michel · Compiègne, FR
• Laurent Schio · Paris, FR

Key dates

• Filing date: Jul 24, 2000
• Grant date: Jan 13, 2004
• Expiry date: Jul 24, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of Formula I in which R1 and R2=H, OH, alkyl optionally substituted, or NR1 forms with the carbon bearing NR1R2 a double bond and R2 is Xra, X being O, NH or N-alkyl and Ra being H, alkyl optionally substituted; R=a chain containing up to 10 carbon atoms, optionally comprising one or several heteroatoms, one or several heterocycles; T=H, CH2, CH2CONH2, CH2C≡, (CH2)2NH2; Y=H, OH, halogen; W=H, OH; Z=H or CH3; said products have antifungal properties.