Humanized antibody against human tissue factor (TF) and process of production of the humanized antibody
US6677436B1 · kind B1 · utility
79Cited by
1References
20Claims
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Key dates
| Filing date | Sep 29, 2000 |
| Grant date | Jan 13, 2004 |
| Priority date | — |
| Expiry date | Sep 29, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a human/mouse chimeric antibody that includes the variable region of a mouse monoclonal antibody against human tissue factor (TF) and the constant region of a human antibody. The humanized antibody contains light and heavy chain complementarity determining regions of a mouse monoclonal antibody against human TF which have been grafted onto a human antibody. The present invention also provides a therapeutic agent for disseminated intravascular coagulation (DIC) syndrome, which includes a humanized antibody against human TF as an active ingredient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.