Amino acid derivatives and methods of making the same

US6677459B2 · kind B2 · utility

Assignee

• Johnson Matthey Pharmaceutical Materials, Inc. · US

Inventors

• Richard L. Gabriel · Swampscott, US
• Jurjus Jurayj · Acton, US

Key dates

• Filing date: Apr 30, 2003
• Grant date: Jan 13, 2004
• Expiry date: Apr 30, 2023

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are novel compounds represented by Structural Formula II, IX or XXVIII: R1, R21, and R22 are independently an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group.R2 is —NR4R5 or —N+≡C−. Alternatively, R1 and R2, taken together with the methine group to which they are bonded, are a moiety represented by the following structural formula: R3 is —NH2, —OH, —OC(O)H or —OR9.R5, R6 and R7 are independently —H or an amine protecting group.R8 is —H, —OH or —OR8.R9 is an alcohol protecting group.Also disclosed are methods of preparing these compounds.