Unified probabilistic framework for predicting and detecting seizure onsets in the brain and multitherapeutic device
US6678548B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 20, 2000 |
| Grant date | Jan 13, 2004 |
| Priority date | — |
| Expiry date | Nov 7, 2020 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16H20/30
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method and an apparatus for predicting and detecting epileptic seizure onsets within a unified multiresolution probabilistic framework, enabling a portion of the device to automatically deliver a progression of multiple therapies, ranging from benign to aggressive as the probabilities of seizure warrant. Based on novel computational intelligence algorithms, a realistic posterior probability function P(St|x) representing the probability of one or more seizures starting within the next T minutes, given observations x derived from IEEG or other signals, is periodically synthesized for a plurality of prediction time horizons. When coupled with optimally determined thresholds for alarm or therapy activation, probabilities defined in this manner provide anticipatory time-localization of events in a synergistic logarithmic-like array of time resolutions, thus effectively circumventing the performance vs. prediction-horizon tradeoff of single-resolution systems. The longer and shorter prediction time scales are made to correspond to benign and aggressive therapies respectively. The imminence of seizure events serves to modulate the dosage and other parameters of treatment during open-loo…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.