Electrical field therapy with reduced histopathological change in muscle
US6678556B1 · kind B1 · utility
110Cited by
63References
38Claims
0Family size
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Key dates
| Filing date | Jun 7, 2002 |
| Grant date | Jan 13, 2004 |
| Priority date | — |
| Expiry date | Sep 16, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61N1/306
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
In vivo methods are provided for using an electric field to delivery therapeutic treatment to a subject while reducing inducement of histopathological change in the target muscle tissue, such as is associated with induction or amplification of an immune response caused by the pulsed electric field. Therapeutic agents can be delivered nto cells of muscle for local and systemic treatments with optimal gene expression and minimal tissue damage. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.