Patent · US Expired

Production of optically active 2-substituted tetrahydropyran-4-ones

US6680183B2 · kind B2 · utility

0Cited by

7References

11Claims

0Family size

Assignee

Zeneca Limited · GB

Inventors

Robert Antony Holt · Billingham, GB
Stuart Richard Rigby · Cross, GB
David Waterson · Bollington, GB

Key dates

Filing date	Jun 1, 2001
Grant date	Jan 20, 2004
Priority date	—
Expiry date	Jul 5, 2021

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12P17/06
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Optically active 2-substituted tetrahydropyran-4-ols or esters thereof may be prepared using esterases or hydrolases from the corresponding racemic mixtures of esters or alcohols. This provides a route to the corresponding optically active ketones.The racemic mixtures are preferably in the cis-form. such mixtures may be produced by reacting but-3-ene-1-ol with an aldehyde in the presence of an acid.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.