Patent · US Expired

Transfer of molecules into the cytosol of cells

US6680301B2 · kind B2 · utility

52Cited by

23References

14Claims

0Family size

Assignee

PHOTOCURE ASA · NO

Inventors

Kristian Berg · Heggedal, NO
Kirsten Sandvik · Oslo, NO
Johan E. Moan · Oslo, NO
Anders Høgset · Oslo, NO

Key dates

Filing date	Sep 1, 1998
Grant date	Jan 20, 2004
Priority date	—
Expiry date	Sep 1, 2018

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P35/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to a method for introducing molecules in cells by disrupting endosomal and lysosomal membranes using photodynamic treatment, without killing the majority of the cells by the photodynamic treatment. More particularly, this invention includes a method for transferring DNA and/or RNA, such as genes, to cells by photochemically inducing the disruption of endosomes and lysosomes.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.