Dihydropyrimidines and uses thereof

US6680323B2 · kind B2 · utility

Assignee

• Synaptic Pharmaceutical Corporation · US

Inventors

• Donghui Cui · Newtown, US
• Margaret R. Davis · Redmond, US
• Michael Dunn · Cambridge, US
• Ben E. Evans · Lansdale, US
• Hanumath P. Kari · Hatfield, US
• Bharat Lagu · Maywood, US
• Dhanapalan Nagarathnam · Bethany, US
• Kamlesh P. Vyas · Harleysville, US
• Kanyin Zhang · San Diego, US

Key dates

• Filing date: Jun 4, 2001
• Grant date: Jan 20, 2004
• Expiry date: Jun 4, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention is directed to dihydropyrimidines which are selective antagonists for human &agr;1a receptors. This invention is also related to uses of these compounds for relaxing lower urinary tract tissue, treating benign prostatic hyperplasia and for the treatment of any disease where the antagonism of the &agr;1a receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.