Hydroxamic and carboxylic acid derivatives

US6680338B2 · kind B2 · utility

Assignee

• Darwin Discovery Limited · GB

Inventors

• John Gary Montana · Harlow, GB
• Andrew Douglas Baxter · Cambridge, GB
• David Alan Owen · Cambridge, GB
• Robert J. Watson · Cambridge, GB

Key dates

• Filing date: Feb 6, 2001
• Grant date: Jan 20, 2004
• Expiry date: Jul 12, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D309/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds having therapeutic utility are of formula (I)B—X—(CH2)n—CR2R3—CR4R5—COY  (I)whereinn=0-1;X is S(O)0-2;Y is OR1 or NHOH;R2 and R4 are independently H or a group (optionally substituted with R10) selected from C1-6 alkyl, C2-6 alkenyl, aryl, C1-6 alkyl-aryl, heteroaryl, C1-6 alkyl-heteroaryl, heterocycloalkyl, C1-6 alkyl-heterocycloalkyl, cycloalkyl and C1-6 alkyl-cycloalkyl; andR1, R3 and R5 are independently H or C1-6 alkyl,provided that not more than two of R2, R3, R4 and R5 are H; orany of CR2R3, CR4R5 and CR2—CR4 is a cycloalkyl or heterocycloalkyl ring optionally substituted with R10 or a group (optionally substituted with R10) selected from C1-6 alkyl, aryl, C1-6 alkyl-aryl, heteroaryl and C1-6 alkyl-heteroaryl;B is heterocycloalkyl (optionally substituted by R6 or R7) bonded through carbon to X, or C1-6 alkyl-heterocycloalkyl (optionally substituted with R6 or R7), or a group (substituted with R6) selected from C1-8 alkyl, C2-6 alkenyl and C2-6 alkynyl;R6 is N(R7)2, OR7, COR7, C(═NOR9)R7, NR7R8, S(O)0-2R9 or SO2N(R7)2;R7 is H or a group selected from C1-6 alkyl, aryl, C1-6 alkyl-aryl, heteroaryl, C1-6 alkyl-hetero…