Methods and compositions for controlled polypeptide synthesis
US6680365B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Mar 19, 1999 |
| Grant date | Jan 20, 2004 |
| Priority date | — |
| Expiry date | Mar 19, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/088
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for making block copolypeptides and related protocols for adding aminoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains by exposing the NCA to solutions containing polyaminoacid chains having an amido amidate metallacyle end groups and reacting the NCA with the amido containing metallacyle end group so that the NCA is added to the polyaminoacid chain. Addition methods include means of controlling the addition of aminoacid-N-carboxyanhydrides to polyaminoacid chains by reacting NCAs with initiator molecules and allowing initiator complexes to open the ring of the NCAs through oxidative addition across either the O—C5 or O—C2 anhydride bond resulting a controlled polypeptide polymerization. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.