Process for the preparation of robenidine and salts thereof
US6680409B2 · kind B2 · utility
0Cited by
3References
16Claims
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Assignee
Inventors
Key dates
| Filing date | Jul 6, 2001 |
| Grant date | Jan 20, 2004 |
| Priority date | — |
| Expiry date | Jul 6, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C277/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a novel method for producing robenidine and salts thereof of the general formula wherein X denotes a halogen atom. The method uses hydrazine hydrate and a cyano compound YCN as the starting materials, which are first reacted to projuce a diaminoguanidine of the general formula wherein Y denotes a halogen atom or tosyl. This diaminoguanidine is then converted directly, without isolation, by reacting with a p-halobenzaldehyde of the general formula IV to produce the robenidine and salts thereof of general formula I.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.