Electrochemical reporter system for detecting analytical immunoassay and molecular biology procedures

US6682648B1 · kind B1 · utility

Assignee

• University of Southern California · US

Inventors

• Robert D. MacPhee · Long Beach, US
• Clive R. Taylor · Hertford, GB
• Rainer Hintsche · Berlin, DE
• Rene Seitz · Itzehoe, DE

Key dates

• Filing date: Jun 26, 1998
• Grant date: Jan 27, 2004
• Expiry date: Jun 26, 2018

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/5438
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

An immunochemical and molecular biologic endpoint reporter system in which reaction products, coupled to electrochemically active molecules susceptible to redox recycling or coupled to enzymes capable of proportional generation of said electrochemically active molecules, are detected and/or quantitated using amperiometry in conjunction with a silicon microchip possessing a closely spaced interdigitated array of nobel metal electrodes.