Low molecular weight inhibitors of complement proteases

US6683055B1 · kind B1 · utility

Assignee

• BASF SE

Inventors

• Heinz Hillen · Herbrechtingen, DE
• Martin Schmidt · Frankfurt am Main, DE
• Helmut Mack · Ludwigshafen, DE
• Werner Seitz · Plankstadt, DE
• Andreas Haupt · Ludwigshafen, DE
• Johann-Christian Zechel · Schallstadt, DE
• Andreas Kling · Mannheim, DE

Key dates

• Filing date: Mar 30, 2000
• Grant date: Jan 27, 2004
• Expiry date: Mar 30, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Peptide substances, their preparation and their use as complement inhibitors are described. These are in particular substances having a guanidine or amidine radical as a terminal group. In particular, inhibitors of the complement proteases C1s and C1r are described.