Composition and treatment method for brain and spinal cord injuries
US6683066B2 · kind B2 · utility
Inventor
Key dates
| Filing date | Sep 24, 2001 |
| Grant date | Jan 27, 2004 |
| Priority date | — |
| Expiry date | Dec 20, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K36/48
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
After interruption of blood supply to central nervous system tissue, cerebral edema sets in. It has been shown that restoring blood flow to injured areas of the central nervous system after the onset of edema does not result in blood reperfusing the tissue. A composition and method for treating injured central nervous tissue, or preventing injury to central nervous system tissue is provided. The composition is generally an amphipathic lipid in an oil solution. The method provides for withdrawing cerebrospinal fluid from the subarachnoid spaces around the tissue to be treated or protected, and replacing that fluid with an approximately equivalent volume of the amphipathic lipid in oil composition. The treatment can be augmented with agents that suppress production of cerebrospinal fluid, or with other known agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.