Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting &bgr;-amyloid peptide release and/or its synthesis by use

US6683075B1 · kind B1 · utility

Assignees

• Athena Neurosciences, Inc. · US
• ELI LILLY AND COMPANY · US

Inventors

• Jing Wu · Mundelein, US
• Jay Tung · Belmont, US
• Eugene D. Thorsett · Moss Beach, US
• Michael A. Pleiss · Sunnyvale, US
• Jeffrey S. Nissen · Indianapolis, US
• R. Jeffrey Neitz · San Francisco, US
• Lee H. Latimer · Oakland, US
• Varghese John · San Francisco, US
• Stephen Freedman · Walnut Creek, US
• Thomas C. Britton · Carmel, US
• James Audia · Indianapolis, US
• Jon K. Reel · Carmel, US
• Thomas E. Mabry · Indianapolis, US
• Bruce A. Dressman · Indianapolis, US
• Cynthia L. Cwi · Indianapolis, US
• James J. Droste · Indianapolis, US
• Steven S. Henry · New Palestine, US
• Stacey L. McDaniel · Martinsville, US
• William Leonard Scott · Indianapolis, US
• Russell Stucky · Indianapolis, US
• Warren J. Porter · Indianapolis, US

Key dates

• Filing date: Jan 6, 2003
• Grant date: Jan 27, 2004
• Expiry date: Jan 6, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.