N-(indole-2-carbonyl)-b-alaninamide crystal forms

US6683106B2 · kind B2 · utility

Assignee

• PFIZER INC. · US

Inventors

• Douglas J. M. Allen · Indianapolis, US
• Frank R. Busch · Gales Ferry, US
• Joseph Francis Krzyzaniak · Pawcatuck, US
• Zheng Li · Quaker Hill, US
• Susan Orrill · Gales Ferry, US
• Peter R. Rose · Ledyard, US
• Derek Tickner · Waterford, US
• Harry Tobiassen · Ledyard, US

Key dates

• Filing date: Apr 15, 2003
• Grant date: Jan 27, 2004
• Expiry date: Apr 15, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The instant invention provides crystal forms of 5-chloro-N-[(1S,2R)-3-[3R,4S]-3,4-dihydroxy-1-pyrrolidinyl]-2-hydroxy-3-oxo-1-(phenyl) methyl)propyl]-1H-indole-2-carboxamide (I) processes for the production of such crystal forms; pharmaceutical compositions comprising such crystal forms; and methods of treating glycogen phosphorylase dependent diseases, or conditions with such crystal forms, or such pharmaceutical compositions.