Variant human &agr;7 acetylcholine receptor subunit, and methods of production and use thereof
US6683157B2 · kind B2 · utility
19Cited by
2References
5Claims
0Family size
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Key dates
| Filing date | Sep 18, 2001 |
| Grant date | Jan 27, 2004 |
| Priority date | — |
| Expiry date | Dec 6, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A variant human &agr;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &agr;7 nAChR. Nucleic acid molecules encoding the variant human &agr;7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.