Coiled-coil dimer derived antagonists of 4-helix bundle cytokines, design and uses thereof

US6685932B1 · kind B1 · utility

Assignee

• Europaeisches Laboratorium Fuer Molekularbiologie (EMBL) · DE

Inventors

• Helena Domingues · Heidelberg, DE
• David Cregut · Strasbourg, FR
• Walter Sebald · Würzburg, DE
• Hartmut Oschkinat · Berlin, DE
• Luis Serrano · Heidelberg, DE

Key dates

• Filing date: May 12, 2000
• Grant date: Feb 3, 2004
• Expiry date: May 12, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The design of antagonists of 4-helix bundle cytokine specific receptors, mimetic peptides that are able to act as such antagonists and their use as pharmaceutical agents is disclosed.