T helper cell epitopes

US6685947B1 · kind B1 · utility

Assignees

• CSL LIMITED · AU
• The University of Melbourne · AU
• COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION · AU
• The Council of the Queensland Institute of Medical Research · AU
• THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH · AU

Inventors

• David Charles Jackson · Elmore, AU
• Souravi Ghosh · Elmore, AU
• John Walker · Memphis, US

Key dates

• Filing date: Mar 22, 2002
• Grant date: Feb 3, 2004
• Expiry date: Mar 22, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/18422
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides T helper cells epitopes and compositions for use in inducing an immune response comprising at least one of these epitopes. The epitopes are contained within a peptide sequence selected from the group consisting of SSKTQTHTQQDRPPQPS (SEQ ID NO:1); QPSTELEETRTSRARHS (SEQ ID NO:2); RHSTTSAQRSTHYDPRT (SEQ ID NO:3); PRTSDRPVSYTMNRTRS (SEQ ID NO:4); TRSRKQTSHRLKNIPVH (SEQ ID NO:5); SHQYLVIKLIPNASLIE (SEQ ID NO:6); IGTDNVHYKIMTRPSHQ (SEQ ID NO:7); YKIMTRPSHQYLVIKLI (SEQ ID NO:8); KLIPNASLIENCTKAEL (SEQ ID NO:9); AELGEYEKLLNSVLEPI (SEQ ID NO:10); KLLNSVLEPINQALTLM (SEQ ID NO:11); EPINQALTLMTKNVKPL (SEQ ID NO:12); FAGVVLAGVALGVATAA (SEQ ID NO:13); GVALGVATAAQITAGIA (SEQ ID NO:14); TMQITAGIALHQSNLN (SEQ ID NO:15); GIALHQSNLNAQAIQSL (SEQ ID NO:16); NLNAQAIQSLRTSLEQS (SEQ ID NO:17); QSLRTSLEQSNKAIEEI (SEQ ID NO:18); EQSNKAIEEIREATQET (SEQ ID NO:19); TELLSIFGPSLRDPISA (SEQ ID NO:20); PRYIATNGYLISNFDES (SEQ ID NO:21); CIRGDTSSCARTLVSGT (SEQ ID NO:22); DESSCVFVSESAICSQN (SEQ ID NO:23); TSTIINQSPDKLLTFIA (SEQ ID NO:24); SPDKLLTFIASDTCPLV (SEQ ID NO:25) and SGRRQRRFAGVVLAGVA (SEQ ID NO:26).