Azaindoles having serotonin receptor affinity
US6686374B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 10, 2000 |
| Grant date | Feb 3, 2004 |
| Priority date | — |
| Expiry date | Aug 10, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D519/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are compounds with affinity for the 5-HT6 receptor, which have the general formula I: wherein:R represents a group of Formula II or Formula III;one of A, B D or E is a N atom, the remainder being CH groups;R1 is selected from the group consisting of SO2Ar, C(O)Ar, CH2Ar and Ar;R2, R3 and R4 are independently selected from the group consisting of H and alkyl; represents a single or double bond, with the proviso that there is only one double bond in the ring at a time;n is an integer of from 1-3;Z is selected from the group consisting of C, CH and N, provided that when is a double bond, Z is C and when is a single bond, Z is selected from CH and N;Ar is an optionally substituted aryl group;with the proviso that when R is a group of Formula II, R1 is SO2Ar.Also described is the use of these compounds as pharmaceuticals to treat indications where inhibition of the 5-HT6 receptor is implicated, such as schizophrenia.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.