Use of a RAR-&ggr;-specific agonist ligand for increasing the rate of apoptosis
US6686386B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 2, 1999 |
| Grant date | Feb 3, 2004 |
| Priority date | — |
| Expiry date | Nov 2, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to pharmaceutical and cosmetic compositions comprising at least one agonist ligand, which is specific for receptors of the RAR-&ggr; type, which are characterized as inducers of apoptosis in at least one cell population in which apoptosis can be induced by activating receptors of the RAR-&ggr; type. In one aspect of the present invention, there is provided a method of combating photoinduced or chronological ageing of skin, said method comprising administering an effective amount of at least one agonist ligand which is specific for receptors of the RAR-&ggr; type to combat photoinduced or chronological aging of skin, wherein the agonist ligand has a ratio R which is equal to or greater than 10.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.