Patent · US Expired

Conjugated peptide nucleic acids having enhanced cellular uptake

US6686442B2 · kind B2 · utility

5Cited by
7References
14Claims
0Family size

Assignee

Inventors

Key dates

Filing dateNov 19, 2001
Grant dateFeb 3, 2004
Priority date—
Expiry dateNov 19, 2021

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2310/3181
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Peptide nucleic acids conjugated to lipophilic groups and incorporated into liposomes exhibit enhanced cellular uptake and distribution. Cellular uptake and distribution of peptide nucleic acids also increases with the introduction of an amino acid side chain into the backbone of peptide nucleic acids. Methods of modulating cellular uptake and methods for treating animals are provided. The peptide nucleic acids of the invention comprise naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.