Compositions and methods for selectively binding amines or amino acid enantiomers over their counter-enantiomers
US6686479B2 · kind B2 · utility
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16References
17Claims
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Key dates
| Filing date | Mar 8, 2001 |
| Grant date | Feb 3, 2004 |
| Priority date | — |
| Expiry date | Apr 2, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D323/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Naphthyl crown ether ligand molecules containing at least two naphthyl groups that are covalently bonded to suitable solid supports and coated by hydrophobic organic solvents are disclosed. These compositions and associated methods are characterized by selectivity of desired amine or amino acid enantiomers over their counter-enantiomers and derivatives. The composition preferably has an &agr;-value greater than or equal to 4. This allows for the separation of such enantiomers with nonchromatographic resin bed separations of three separation stages or less.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.