Stabilized interleukin 2
US6689353B1 · kind B1 · utility
67Cited by
5References
6Claims
0Family size
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Key dates
| Filing date | Jun 28, 2000 |
| Grant date | Feb 10, 2004 |
| Priority date | — |
| Expiry date | Mar 3, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A stable pharmaceutical preparation comprising Human interleukin-2 or a variant thereof and a stabilizing amount of histidine. A preferred formulation includes glycine and sucrose and a variant of IL-2 having a single mutation, N88R. The preferred formulation is in lyophilized form which, on reconstitution with an aqueous diluent, results in a solution having a pH ranging from about 5.0 to 6.5.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.