Polynucleotide molecules encoding proteins having proteinase inhibitor activity
US6689582B1 · kind B1 · utility
29Cited by
1References
6Claims
0Family size
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Key dates
| Filing date | May 12, 2000 |
| Grant date | Feb 10, 2004 |
| Priority date | — |
| Expiry date | May 12, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
BTL.010 is a novel human serine proteinase inhibitor of the Kunitz family that exhibits greater potency towards neutral serine proteinases, particularly leukocyte elastase and proteinase 3 than towards trypsin-like proteinases. BTL.010, or variants thereof, may be employed as therapeutics in diseases such as emphysema, idiopathic pulmonary fibrosis, adult respiratory distress syndrome, cystic fibrosis, rheumatoid arthritis, organ failure, and glomerulonephritis in which uncontrolled proteolysis due to neutral serine proteinase activity results in tissue damage.
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