Method of stabilizing biologically active substances

US6689755B1 · kind B1 · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Rolf-Dieter Gabel · Schwetzingen, DE
• Markus Mattern · Heppenheim, DE
• Gerhard Winter · Dossenheim, DE
• Alexander Wirl · Heuchelheim, DE
• Heinrich Woog · Hemsbach, DE

Key dates

• Filing date: Nov 3, 1998
• Grant date: Feb 10, 2004
• Expiry date: Nov 3, 2018

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/81
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a rapid and readily reproducible process for stabilizing biologically active substances by combining the biologically active substance witha a stabilizingmixture and drying the resulting mixture into a dry, amorphous product by means of convection drying. The invention also relates to the amorphous, microscopically homogeneous products which are obtained by this process, are in the form of powders and have a uniform geometric, in particular spherical, shape. The invention furthermore relates to the use of substance mixtures for stabilizing biologically active material, in particular proteins by means of spray drying.