Polymorphs of an epothilone analog

US6689802B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• John D. DiMarco · East Brunswick Township, US
• Jack Z. Gougoutas · Princeton, US
• Imre Vitez · Whitehouse Station, US
• Martha Davidovich · East Brunswick Township, US
• Michael Galella · Kendall Park, US
• Timothy M. Malloy · Yardley, US
• Zhenrong Guo · East Brunswick Township, US
• Denis Favreau · St-Hubert, CA

Key dates

• Filing date: Aug 9, 2001
• Grant date: Feb 10, 2004
• Expiry date: Aug 9, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

There are provided in accordance with the present invention two crystalline polymorphs, designated Form A and Form B, respectively, as well as mixtures thereof, of an epothilone analog represented by the formula Also provided are methods of forming the novel polymorphs, therapeutic methods utilizing them and pharmaceutical dosage forms containing them.