Halogen-modified silicon, surfaces

US6689858B2 · kind B2 · utility

Assignee

• Wisconsin Alumni Research Foundation · US

Inventors

• Robert J. Hamers · Madison, US
• Wei-Wen Cai · Houston, US
• Lloyd M. Smith · Atlanta, US
• Todd C. Strother · Cottage Grove, US

Key dates

• Filing date: Jan 26, 2001
• Grant date: Feb 10, 2004
• Expiry date: Sep 14, 2021

Classification

• Technology area (CPC H): Electricity
• CPC primary: H10K85/761
• WIPO field: Micro-structural and nano-technology
• WIPO sector: Chemistry

Abstract

Chemically-modified surfaces on unoxidized, bromine- or iodine-terminated carbon, silicon, and germanium substrates are disclosed. Visible light mediates the reaction of protected &ohgr;-modified, &agr;-unsaturated aminoalkenes (preferred) with bromine- or iodine-terminated carbon, silicon, or germanium surfaces. Removal of the protecting group yields an aminoalkane-modified silicon surface. These amino groups can be coupled to terminal-modified oligonucleotides using a bifunctional crosslinker, thereby permitting the preparation of modified surfaces and arrays. Methods for controlling the surface density of molecules attached to the substrate are also disclosed.