Preparation of amines

US6689914B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Martin Schäfer · Arnstadt, DE
• Arnd Bottcher · Bischofswerda, DE
• Andreas Kramer · Zürich, CH
• Arthur Hohn · Tauberbischofsheim, DE
• Shelue Liang · Ludwigshafen, DE
• Frank Funke · Bischofswerda, DE

Key dates

• Filing date: Sep 5, 2002
• Grant date: Feb 10, 2004
• Expiry date: Sep 5, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C209/26
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The preparation of amines of the formula (I):R1R2CH—N R3R4  (I)in which R1, R2, R3 and R4, independently of one another, are hydrogen, straight-chain or branched C1-C12-alkyl, C3-C12-cycloalkyl, C6-C10-aryl or C7-C11-aralkyl, takes place by catalytic, reductive amination of mixtures comprising carbonyl compounds of the formula (II) and/or alcohols of the formula (III)R1—C(═O)—R2  (II)R1—CH(OH)—R2  (III)which also comprise at least 50 ppm, based on the mixtures, of halogen, with nitrogen compounds of the formula (IV):H N R3 R4  (IV)with the abovementioned meanings for R1 to R4, in the presence of Co- and/or Ni-containing catalysts, which comprises carrying out the reductive amination additionally in the presence of solid acidic cocatalysts.