Method and apparatus for multiple electrospray sample introduction
US6690006B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | May 23, 2002 |
| Grant date | Feb 10, 2004 |
| Priority date | — |
| Expiry date | May 23, 2022 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/628
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for the coupling of a plurality of sample streams eluting from a plurality of High Pressure Liquid Chromatography columns into a single inlet mass spectrometer, wherein samples from individual chromatography columns are suppled to individual electrospray nozzles in an array of a plurality of electrospray nozzles positioned in front of said single inlet, each nozzle being switchable to an on or off state, and each nozzle being supplied by a sample supply tube or channel and having, in addition to said sample supply tube or channel, a separate fluid removal tube or channel, and wherein each nozzle, when in the off state, is held at a voltage that is between the voltage of the mass spectrometer inlet and the electrospray threshold value for that nozzle.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.