Recombinant glycoproteins, method for the production thereof, medicaments containing said glycoproteins and use thereof

US6692931B1 · kind B1 · utility

Assignee

• Werner Reutter · DE

Inventors

• Werner Reutter · Berlin, DE
• Rudolf Tauber · Berlin, DE
• Rüdiger Horstkorte · Berlin, DE
• Sabine Nöhring · Selters (Westerwald), DE
• Martin GOHLKE · Berlin, DE
• Rolf Nuck · Berlin, DE
• Richard Schmidt · Konstanz, DE
• Charlotte Hauser · Thuwal, SA

Key dates

• Filing date: Dec 13, 2001
• Grant date: Feb 17, 2004
• Expiry date: Dec 13, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to novel recombinant glycoproteins that act as messenger substances, signaling substances, promoters, stimulators and initiators in a multitude of ways in the animal, especially human, circulation system. The invention also relates to a method for the production thereof, pharmaceutical agents containing said glycoproteins and the use thereof The invention more particularly relates to novel recombinant human glycoproteins (rh glycoproteins), preferably novel rh differentiation factors, especially rh erythropoietin; novel rh growth factors, especially rh CSF (colony stimulating factor), rh GMCSF (granulocytes monocytes stimulation factor); novel rh thrombolytic agents, especially rh tPA (tissue plasminogen activator) and rh urokinase; novel rh thromboprophylactic agents, especially rh antithrombin III; novel rh coagulation factors, especially rh factor VIII and rh factor IX; novel rh interferons, especially rh &agr;, &bgr; and &ggr; interferons; and novel rh interleukins, especially rh IL-2, IL-15, IL-16 and IL-17. The invention further relates to a method for the production of said substances, pharmaceutical agents containing them and to the use thereof.