Method for diagnosing bone dysbolism
US6693175B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 24, 1999 |
| Grant date | Feb 17, 2004 |
| Priority date | — |
| Expiry date | Jun 23, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/809
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of diagnosing metabolic bone diseases, especially osteoporosis and arthrosis characterized by determining the concentration of osteoclastgenesis inhibitory factor (OCIF) in humor.Monoclonal antibodies recognizing equally both of monomer type and dimer type of OCIF. Monoclonal antibodies recognizing selectively dimer type of OCIF. And to provide an assay kit for determination of OCIF concentration comprising the aforementioned two antibodies recognizing different epitope of OCIF and having high affinity showing dissociation constant of less than 2×10−7 M with antigen. It is useful for a method of diagnosing metabolic bone diseases, especially osteoporosis and arthrosis or for an assay reagent for research thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.