Materials and method for treating or preventing pathogenic fungal infection

US6693189B2 · kind B2 · utility

Assignee

• ARIAD Gene Therapeutics, Inc. · US

Inventors

• Dennis A. Holt · Downingtown, US
• Terence P. Keenan · Cambridge, US
• Timothy Piers Clackson · Cambridge, US
• Leonard W. Rozamus · Andover, US
• Wu Yang · Ann Arbor, US
• Michael Z. Gilman · Newton, US

Key dates

• Filing date: Jul 10, 2001
• Grant date: Feb 17, 2004
• Expiry date: Jul 10, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention concerns derivatives of rapamycin and their antifungal uses. Also disclosed are materials and methods relevant to the identification of non-immunosuppressive anti-fungal rapamycin derivatives. Use of compounds, among others, of the formula is disclosed, where the various substitutents are as defined.