Method of making HIV protease inhibitors

US6693199B2 · kind B2 · utility

Assignee

• Agouron Pharmaceuticals, Inc. · US

Inventors

• Bruce A. Dressman · Indianapolis, US
• James E. Fritz · Greenwood, US
• Marlys Hammond · Blue Bell, US
• William J. Hornback · Indianapolis, US
• Stephen W. Kaldor · Indianapolis, US
• Vincent Jacob Kalish · Annapolis, US
• John E. Munroe · Indianapolis, US
• Siegfried H. Reich · San Diego, US
• John Howard Tatlock · San Diego, US
• Timothy Alan Shepherd · Indianapolis, US
• Michael Rodriguez · Arlington Heights, US

Key dates

• Filing date: Nov 21, 2002
• Grant date: Feb 17, 2004
• Expiry date: Feb 17, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/62
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A method of making HIV protease inhibitors of general formula (1): These HIV compounds inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optically other antiviral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.