Microfluidic channel embryo and/or oocyte handling, analysis and biological evaluation

US6695765B1 · kind B1 · utility

Assignee

• The Board of Trustees of the University of Illinois · US

Inventors

• David J. Beebe · Monona, US
• Ian K. Glasgow · Averill Park, US
• Matthew B. Wheeler · Tolono, US
• Henry Zeringue · Madison, US

Key dates

• Filing date: May 12, 2000
• Grant date: Feb 24, 2004
• Expiry date: May 12, 2020

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01L2400/086
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Microfluidic embryo scaled channels for handling and positioning embryos provide the opportunity to evaluate and treat embryos in improved manners Fluid flow is used to move and position embryos within microfluidic channels and channel geometries may be used to place embryos at specific locations. Surface properties and compliance (deformation) properties of embryos are evaluated as a predictor of viability. The microfluidic channels provide the opportunity for fine controls of pressure to conduct various evaluations at forces slightly below which damage to embryos is known to occur.