Pyrogenicity test for use with automated immunoassay systems
US6696261B2 · kind B2 · utility
18Cited by
4References
20Claims
0Family size
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Key dates
| Filing date | Dec 1, 2000 |
| Grant date | Feb 24, 2004 |
| Priority date | — |
| Expiry date | Oct 11, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/6863
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention concerns an improved pyrogenicity test for use in automated immunoassay systems, in which a sample is incubated with a monocyte-containing reagent in a pyrogen-free assay system preferably comprising a surface coated with pyrogen-free anti-cytokine antibodies. The invention also concerns pyrogen-free assay systems coated with pyrogen-free antibodies for use in these tests. The invention also relates to a test to measure the basal production of endogenous mediators of the inflammatory response by leukocytes and a method of measuring the capacity of a leukocyte to respond to a stimuli.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.