Synthetic HIV gag genes

US6696291B2 · kind B2 · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• John Shiver · Doylestown, US
• Daniel C. Freed · Limerick, US
• Mary Davies · Norristown, US
• Margaret A. Liu · Rosemont, US
• Helen Perry · Lansdale, US

Key dates

• Filing date: Oct 9, 2001
• Grant date: Feb 24, 2004
• Expiry date: Oct 9, 2021

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Synthetic DNA molecules encoding HIV gag and modifications of HIV gag are provided. The codons of the synthetic molecules are codons preferred by the projected host cell. The synthetic molecules may be used as a polynucleotide vaccine which provides effective immunoprophylaxis against HIV infection through stimulation of neutralizing antibody and cell-mediated immunity.