Benzoylpyridazines, their preparation and use

US6696446B1 · kind B1 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Rochus Jonas · Darmstadt, DE
• Michael Wolf · Darmstadt, DE
• Norbert Beier · Reinheim, DE

Key dates

• Filing date: Jan 9, 2002
• Grant date: Feb 24, 2004
• Expiry date: Feb 5, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D237/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Benzoyl derivatives of formula (I) and their physiologically acceptable salts and solvates, in which R1, R2, R3, R4, R5 and R6 have the meanings indicated,inhibit phosphodiesterase IV and can be used for the treatment of allergic diseases, asthma, chronic bronchitis, atopic dermatitis, psoriasis and other skin diseases, inflammatory diseases, auto-immune diseases such as rheumatoid arthritis, multiple sclerosis, Crohn's disease, diabetes mellitus or ulcerative colitis, osteoporosis, transplant rejection reactions, cachexia, tumoral growth or tumoral metastases, septicemia, memory defects, atherosclerosis and AIDS.